In vivo tracking of stem cells labeled with a nanoparticle in Alzheimer’s disease animal model

Sungji Ha; Yoo-Hun Suh; Keun-A Chang

doi:10.1117/12.2019458

20 May 2013 In vivo tracking of stem cells labeled with a nanoparticle in Alzheimer’s disease animal model

Sungji Ha, Yoo-Hun Suh, Keun-A Chang

Proceedings Volume 8879, Nano-Bio Sensing, Imaging, and Spectroscopy; 887911 (2013) https://doi.org/10.1117/12.2019458
Event: Nano-Bio Sensing, Imaging and Spectroscopy, 2013, Jeju, Korea, Republic of

Abstract

Stem cell therapy is a promising tool for the treatment of diverse conditions including neurodegenerative diseases. To understand transplanted stem cell biology, in vivo imaging is necessary. Nano material has great potential for in vivo imaging and several noninvasive methods are used such as magnetic resonance imaging (MRI), positron emission tomography (PET), Fluorescence imaging (FI) and Near-infrared fluorescence imaging (NIRFI). However, each method has limitations for in vivo imaging. To overcome these limitations, multimodal nanoprobes have been developed. In the present study, we intravenously injected human adipose derived stem cells (hASCs) that labeled with multimodal nano particle, LEO-LIVE^TM-Magnoxide 797 or 675, into the Tg2576 mice, Alzheimer’s disease (AD) mouse model. Sequential in vivo tracking was performed with mice injected with hASCs. We could found fluorescence signals until 10 days after injection.

Citation Download Citation

Sungji Ha, Yoo-Hun Suh, and Keun-A Chang "In vivo tracking of stem cells labeled with a nanoparticle in Alzheimer’s disease animal model", Proc. SPIE 8879, Nano-Bio Sensing, Imaging, and Spectroscopy, 887911 (20 May 2013); https://doi.org/10.1117/12.2019458

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