Reflectance spectroscopy for evaluating hair follicle cycle

Caihua Liu; Yue Guan; Jianru Wang; Dan Zhu

doi:10.1117/12.2038045

26 February 2014 Reflectance spectroscopy for evaluating hair follicle cycle

Caihua Liu, Yue Guan, Jianru Wang, Dan Zhu

Proceedings Volume 8942, Dynamics and Fluctuations in Biomedical Photonics XI; 894210 (2014) https://doi.org/10.1117/12.2038045
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Hair follicle, as a mini-organ with perpetually cycling of telogen, anagen and catagen, provides a valuable experimental model for studying hair and organ regeneration. The transition of hair follicle from telogen to anagen is a significant sign for successful regeneration. So far discrimination of the hair follicle stage is mostly based on canonical histological examination and empirical speculation based on skin color. Hardly a method has been proposed to quantitatively evaluate the hair follicle stage. In this work, a commercial optical fiber spectrometer was applied to monitor diffuse reflectance of mouse skin with hair follicle cycling, and then the change of reflectance was obtained. Histological examination was used to verify the hair follicle stage. In comparison with the histological examination, the skin diffuse reflectance was relatively high for mouse with telogen hair follicles; it decreased once hair follicles transited to anagen stage; then it increased reversely at catagen stage. This study provided a new method to quantitatively evaluate the hair follicle stage, and should be valuable for the basic and therapeutic investigations on hair regeneration.

Citation Download Citation

Caihua Liu, Yue Guan, Jianru Wang, and Dan Zhu "Reflectance spectroscopy for evaluating hair follicle cycle", Proc. SPIE 8942, Dynamics and Fluctuations in Biomedical Photonics XI, 894210 (26 February 2014); https://doi.org/10.1117/12.2038045

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KEYWORDS

Skin

Reflectivity

Diffuse reflectance spectroscopy

Reflectance spectroscopy

In vivo imaging

Spectroscopy

Biomedical optics

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