Design and fabrication of tri-axial capillary needles in flow focusing for microencapsulation of multiple drugs and imaging agents

Ting Si; Hanxin Feng; Bin Xie; Ronald Xu

doi:10.1117/12.2041065

6 March 2014 Design and fabrication of tri-axial capillary needles in flow focusing for microencapsulation of multiple drugs and imaging agents

Ting Si, Hanxin Feng, Bin Xie, Ronald Xu

Author Affiliations +

Proceedings Volume 8976, Microfluidics, BioMEMS, and Medical Microsystems XII; 89760Q (2014) https://doi.org/10.1117/12.2041065
Event: SPIE MOEMS-MEMS, 2014, San Francisco, California, United States

Abstract

Microencapsulation of multiple drugs and imaging agents is significant for various biomedical applications. In this work we describe a novel method based on flow focusing geometry using tri-axial metallic capillary needles manufactured by a laser beam welding process. The tri-axial needle can be readily cleaned, assembled, and aligned. With this needle assembly, we develop a tri-axial capillary flow focusing device in which different combinations of liquids are focused in the core of a high-speed gas stream coflowing through a small orifice. Under appropriate working conditions, stable cone-jet configurations with three layers of liquids in an external gas stream can be obtained, resulting in multilayered microparticles with outer shell, middle layer, and inner core. The new design of tri-axial needles enables reliable encapsulation of multiple drugs and imaging agents in biodegradable microcapsules with the enhanced size distribution, increased productivity, and improved drug-loading efficiency. Furthermore, in this method the outer and the middle shell fluids can be released to produce monodisperse microparticles at smaller scales which have potential applications in multi-modal imaging, drug delivery, material processing and biomedicine.

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Ting Si, Hanxin Feng, Bin Xie, and Ronald Xu "Design and fabrication of tri-axial capillary needles in flow focusing for microencapsulation of multiple drugs and imaging agents", Proc. SPIE 8976, Microfluidics, BioMEMS, and Medical Microsystems XII, 89760Q (6 March 2014); https://doi.org/10.1117/12.2041065

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KEYWORDS

Liquids

Capillaries

Microfluidics

Multilayers

Multimodal imaging

Manufacturing

Microfluidic imaging

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