Continuous Monitoring Of Cardiogreen Removal By A Diseased Liver Using An Optical Sensor

Masahiko Kanda; Kunihiko Taniguchi; Kunio Awazu; Yoshitaka Ishigami; Manabu Masuzawa; Hiroshi Abe

doi:10.1117/12.945229

8 April 1988 Continuous Monitoring Of Cardiogreen Removal By A Diseased Liver Using An Optical Sensor

Masahiko Kanda, Kunihiko Taniguchi, Kunio Awazu, Yoshitaka Ishigami, Manabu Masuzawa, Hiroshi Abe

Proceedings Volume 0904, Microsensors and Catheter-Based Imaging Technology; (1988) https://doi.org/10.1117/12.945229
Event: 1988 Los Angeles Symposium: O-E/LASE '88, 1988, Los Angeles, CA, United States

Abstract

A non-invasive monitoring instrument of Cardiogreen (Indocyanine green) dye removal by a liver, which uses a new optical sensor and analytical method, was developed. The optical sensor utilizes 2 light emitting diodes operating at 810 and 940 nm wavelength, and 1 photodiode to sample the transmittance of light through the tip of the index finger. Since the transmittance of light is affected most by changes in both blood volume and the concentration of the dye in blood, adequate analysis must be taken to eliminate the change of blood volume in vivo. Fortunately, for a wavelength near the 805 nm isobestic wavelength, the transmittance of light does not vary with hemoglobin oxygen saturation, however it varies with hemoglobin content. In addition, at 805 nm wavelength, absorption by the dye is quite high, but it is quite low at 940 nm wavelength. Accordingly, the authors developed a new analytical. method by using the transmittance of light measured through the tip of the index finger before and after the dye injection. As a result, the change of blood volume in vivo was eliminated by using the newly developed analytical method. Therefore, the dye information was only measured. A quantitative estimation of plasma disappearance rate (PDR) in hepatic diseased patients which was obtained using this instrument showed that PDR values concurred fairly well with the PDR values from the blood sampling method.

Citation Download Citation

Masahiko Kanda, Kunihiko Taniguchi, Kunio Awazu, Yoshitaka Ishigami, Manabu Masuzawa, and Hiroshi Abe "Continuous Monitoring Of Cardiogreen Removal By A Diseased Liver Using An Optical Sensor", Proc. SPIE 0904, Microsensors and Catheter-Based Imaging Technology, (8 April 1988); https://doi.org/10.1117/12.945229

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