Depth sensitive oblique polarized reflectance spectroscopy of oral epithelial tissue

Maria K. Jimenez; Sylvia Lam; Catherine Poh D.D.S.; Konstantin Sokolov

doi:10.1117/12.2057584

19 May 2014 Depth sensitive oblique polarized reflectance spectroscopy of oral epithelial tissue

Maria K. Jimenez, Sylvia Lam, Catherine Poh D.D.S., Konstantin Sokolov

Proceedings Volume 9155, Translational Biophotonics; 91550N (2014) https://doi.org/10.1117/12.2057584
Event: SPIE Translational Biophotonics, 2014, Houston, Texas, United States

Abstract

Identifying depth-dependent alterations associated with epithelial cancerous lesions can be challenging in the oral cavity where variable epithelial thicknesses and troublesome keratin growths are prominent. Spectroscopic methods with enhanced depth resolution would immensely aid in isolating optical properties associated with malignant transformation. Combining multiple beveled fibers, oblique collection geometry, and polarization gating, oblique polarized reflectance spectroscopy (OPRS) achieves depth sensitive detection. We report promising results from a clinical trial of patients with oral lesions suspected of dysplasia or carcinoma demonstrating the potential of OPRS for the analysis of morphological and architectural changes in the context of multilayer, epithelial oral tissue.

Citation Download Citation

Maria K. Jimenez, Sylvia Lam, Catherine Poh D.D.S., and Konstantin Sokolov "Depth sensitive oblique polarized reflectance spectroscopy of oral epithelial tissue", Proc. SPIE 9155, Translational Biophotonics, 91550N (19 May 2014); https://doi.org/10.1117/12.2057584

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