Improvements in frequency-domain based NIRF optical tomography modality for preclinical studies

Chinmay D. Darne; Eva M. Sevick-Muraca

doi:10.1117/12.2057809

19 May 2014 Improvements in frequency-domain based NIRF optical tomography modality for preclinical studies

Proceedings Volume 9155, Translational Biophotonics; 91551D (2014) https://doi.org/10.1117/12.2057809
Event: SPIE Translational Biophotonics, 2014, Houston, Texas, United States

Abstract

Herein we present recent improvements in system design and performance evaluation of near-infrared fluorescence (NIRF) frequency-domain photon migration (FDPM) system developed for small animal fluorescence tomography and installed within a commercial micro-CT/PET scanner. We improved system performance by increasing signal-to-noise ratio (SNR) through use of high powered rf modulation, novel data collection scheme, and data discrimination based on the associated noise levels. Noise characteristics show improvement with these techniques and are currently being employed to improve 3-D fluorescence for tomographic reconstructions in phantoms before incorporating into hybrid scanner.

Citation Download Citation

Chinmay D. Darne and Eva M. Sevick-Muraca "Improvements in frequency-domain based NIRF optical tomography modality for preclinical studies", Proc. SPIE 9155, Translational Biophotonics, 91551D (19 May 2014); https://doi.org/10.1117/12.2057809

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