Characterization of hemodynamics and oxygenation in the renal cortex of rats

Dirk Grosenick; Heidrun Wabnitz; Rainer Macdonald; Thoralf Niendorf; Kathleen Cantow; Bert Flemming; Karen Arakelyan; Erdmann Seeliger

doi:10.1117/12.2076148

5 March 2015 Characterization of hemodynamics and oxygenation in the renal cortex of rats

Dirk Grosenick, Heidrun Wabnitz, Rainer Macdonald, Thoralf Niendorf, Kathleen Cantow, Bert Flemming, Karen Arakelyan, Erdmann Seeliger

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Proceedings Volume 9319, Optical Tomography and Spectroscopy of Tissue XI; 93191C (2015) https://doi.org/10.1117/12.2076148
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We have performed a pre-clinical study on 13 rats to investigate the potential of near-infrared spectroscopy for quantification of hemoglobin concentration and oxygen saturation of hemoglobin in the renal cortex of small animals. These measurements were combined with laser-Doppler fluxmetry and a fluorescence quenching technique for quantification of tissue oxygen tension. Hemoglobin concentration and oxygen saturation were determined from experimental data by a Monte Carlo model. The methods were applied to investigate and compare temporal changes during several types of interventions such as arterial and venous occlusions, as well as hyperoxia, hypoxia and hypercapnia induced by different mixtures of the inspired gas.

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Dirk Grosenick, Heidrun Wabnitz, Rainer Macdonald, Thoralf Niendorf, Kathleen Cantow, Bert Flemming, Karen Arakelyan, and Erdmann Seeliger "Characterization of hemodynamics and oxygenation in the renal cortex of rats", Proc. SPIE 9319, Optical Tomography and Spectroscopy of Tissue XI, 93191C (5 March 2015); https://doi.org/10.1117/12.2076148

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KEYWORDS

Oxygen

Tissues

Near infrared spectroscopy

Blood

Kidney

Laser tissue interaction

Hemodynamics

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