Rapid diagnostic imaging and pathologic evaluation of whole core biopsies at the point-of-care using structured illumination microscopy

Mei Wang; Andrew B. Sholl; Hillary Kimbrell; David B. Tulman; Katherine N. Elfer; J. Quincy Brown

doi:10.1117/12.2183825

15 July 2015 Rapid diagnostic imaging and pathologic evaluation of whole core biopsies at the point-of-care using structured illumination microscopy

Mei Wang, Andrew B. Sholl, Hillary Kimbrell, David B. Tulman, Katherine N. Elfer, J. Quincy Brown

Author Affiliations +

Proceedings Volume 9537, Clinical and Biomedical Spectroscopy and Imaging IV; 95370A (2015) https://doi.org/10.1117/12.2183825
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

Video-rate structured illumination microscopy (VR-SIM) of fluorescently stained prostate biopsies is demonstrated as a potential tool for rapid diagnosis of prostate biopsies at the point of care. Images of entire biopsies at 1.3 micron lateral resolution are rendered in seconds, and pathologist review of the resulting images achieves 90% accuracy as compared to gold standard histopathology.

Citation Download Citation

Mei Wang, Andrew B. Sholl, Hillary Kimbrell, David B. Tulman, Katherine N. Elfer, and J. Quincy Brown "Rapid diagnostic imaging and pathologic evaluation of whole core biopsies at the point-of-care using structured illumination microscopy", Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 95370A (15 July 2015); https://doi.org/10.1117/12.2183825

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