4D optical coherence tomography of aortic valve dynamics in a murine mouse model ex vivo

Christian Schnabel; Anett Jannasch; Saskia Faak; Thomas Waldow; Edmund Koch

doi:10.1117/12.2181361

9 July 2015 4D optical coherence tomography of aortic valve dynamics in a murine mouse model ex vivo

Christian Schnabel, Anett Jannasch, Saskia Faak, Thomas Waldow, Edmund Koch

Proceedings Volume 9541, Optical Coherence Imaging Techniques and Imaging in Scattering Media; 95410V (2015) https://doi.org/10.1117/12.2181361
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

The heart and its mechanical components, especially the heart valves and leaflets, are under enormous strain during lifetime. Like all highly stressed materials, also these biological components undergo fatigue and signs of wear, which impinge upon cardiac output and in the end on health and living comfort of affected patients. Thereby pathophysiological changes of the aortic valve leading to calcific aortic valve stenosis (AVS) as most frequent heart valve disease in humans are of particular interest. The knowledge about changes of the dynamic behavior during the course of this disease and the possibility of early stage diagnosis could lead to the development of new treatment strategies and drug-based options of prevention or therapy. ApoE-/- mice as established model of AVS versus wildtype mice were introduced in an ex vivo artificially stimulated heart model. 4D optical coherence tomography (OCT) in combination with high-speed video microscopy were applied to characterize dynamic behavior of the murine aortic valve and to characterize dynamic properties during artificial stimulation. OCT and high-speed video microscopy with high spatial and temporal resolution represent promising tools for the investigation of dynamic behavior and their changes in calcific aortic stenosis disease models in mice.

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Christian Schnabel, Anett Jannasch, Saskia Faak, Thomas Waldow, and Edmund Koch "4D optical coherence tomography of aortic valve dynamics in a murine mouse model ex vivo", Proc. SPIE 9541, Optical Coherence Imaging Techniques and Imaging in Scattering Media, 95410V (9 July 2015); https://doi.org/10.1117/12.2181361

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KEYWORDS

Optical coherence tomography

Heart

Tissues

Video microscopy

Visualization

3D image processing

Mouse models

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