Identification of GI cancers utilising rapid mid-infrared spectral imaging

Jayakrupakar Nallala; Gavin R. Lloyd; Catherine Kendall; Hugh Barr M.D.; Neil Shepherd; Nick Stone

doi:10.1117/12.2209363

7 March 2016 Identification of GI cancers utilising rapid mid-infrared spectral imaging

Jayakrupakar Nallala, Gavin R. Lloyd, Catherine Kendall, Hugh Barr M.D., Neil Shepherd, Nick Stone

Proceedings Volume 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis; 970303 (2016) https://doi.org/10.1117/12.2209363
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Pathologists find it notoriously difficult to provide both inter- and intra-observer agreement on a diagnosis of early gastrointestinal cancers. Vibrational spectroscopic approaches have shown their value in providing molecular compositional data from tissue samples and therefore enabling the identification of disease specific changes, when combined with multivariate techniques. Mid-infrared microscopic imaging is undergoing rapid developments in sources, detectors and spectrometers. Here we explore the use of high magnification FTIR for GI cancers and consider how the MINERVA (MId- to NEaR infrared spectroscopy for improVed medical diAgnostics) project, which is developing discrete frequency IR imaging tools will enable histopathologists to obtain rapid molecular images form unstained tissue sections.

Conference Presentation

Citation Download Citation

Jayakrupakar Nallala, Gavin R. Lloyd, Catherine Kendall, Hugh Barr M.D., Neil Shepherd, and Nick Stone "Identification of GI cancers utilising rapid mid-infrared spectral imaging", Proc. SPIE 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 970303 (7 March 2016); https://doi.org/10.1117/12.2209363

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