The Raman spectrum character of skin tumor induced by UVB

Shulian Wu; Liangjun Hu; Yunxia Wang; Yongzeng Li

doi:10.1117/12.2208890

7 March 2016 The Raman spectrum character of skin tumor induced by UVB

Shulian Wu, Liangjun Hu, Yunxia Wang, Yongzeng Li

Proceedings Volume 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis; 97031Y (2016) https://doi.org/10.1117/12.2208890
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

In our study, the skin canceration processes induced by UVB were analyzed from the perspective of tissue spectrum. A home-made Raman spectral system with a millimeter order excitation laser spot size combined with a multivariate statistical analysis for monitoring the skin changed irradiated by UVB was studied and the discrimination were evaluated. Raman scattering signals of the SCC and normal skin were acquired. Spectral differences in Raman spectra were revealed. Linear discriminant analysis (LDA) based on principal component analysis (PCA) were employed to generate diagnostic algorithms for the classification of skin SCC and normal. The results indicated that Raman spectroscopy combined with PCA-LDA demonstrated good potential for improving the diagnosis of skin cancers.

Citation Download Citation

Shulian Wu, Liangjun Hu, Yunxia Wang, and Yongzeng Li "The Raman spectrum character of skin tumor induced by UVB", Proc. SPIE 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 97031Y (7 March 2016); https://doi.org/10.1117/12.2208890

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KEYWORDS

Skin

Raman spectroscopy

Tumors

Tissues

Skin cancer

Collagen

Proteins

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