Diffuse light tomography to detect blood vessels using Tikhonov regularization

Huseyin Ozgur Kazanci; Steven L. Jacques

doi:10.1117/12.2230074

21 April 2016 Diffuse light tomography to detect blood vessels using Tikhonov regularization

Huseyin Ozgur Kazanci, Steven L. Jacques

Proceedings Volume 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS); 99170T (2016) https://doi.org/10.1117/12.2230074
Event: Saratov Fall Meeting 2015, 2015, Saratov, Russian Federation

Abstract

Detection of blood vessels within light-scattering tissues involves detection of subtle shadows as blood absorbs light. These shadows are diffuse but measurable by a set of source-detector pairs in a spatial array of sources and detectors on the tissue surface. The measured shadows can reconstruct the internal position(s) of blood vessels.

The tomographic method involves a set of N_s sources and N_d detectors such that N_sd = N_s x N_dsource-detector pairs produce N_sd measurements, each interrogating the tissue with a unique perspective, i.e., a unique region of sensitivity to voxels within the tissue.

This tutorial report describes the reconstruction of the image of a blood vessel within a soft tissue based on such source-detector measurements, by solving a matrix equation using Tikhonov regularization. This is not a novel contribution, but rather a simple introduction to a well-known method, demonstrating its use in mapping blood perfusion.

Citation Download Citation

Huseyin Ozgur Kazanci and Steven L. Jacques "Diffuse light tomography to detect blood vessels using Tikhonov regularization", Proc. SPIE 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS), 99170T (21 April 2016); https://doi.org/10.1117/12.2230074

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