Adaptive optics: optical coherence tomography imaging of the inner retina in multiple sclerosis

Daniel X. Hammer; Zhuolin Liu; Katherine Kovalick; Osamah Saeedi; Daniel M. Harrison

doi:10.1117/12.2608765

7 March 2022 Adaptive optics: optical coherence tomography imaging of the inner retina in multiple sclerosis

Daniel X. Hammer, Zhuolin Liu, Katherine Kovalick, Osamah Saeedi, Daniel M. Harrison

Proceedings Volume PC11941, Ophthalmic Technologies XXXII; PC1194106 (2022) https://doi.org/10.1117/12.2608765
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Multiple sclerosis (MS) is a debilitating autoimmune disease characterized by lesions found in different regions of the central nervous system caused by overactive immune cells. MS also manifests in the retina, in which optic nerve pathology (such as optic neuritis) and neurodegenerative processes can affect inner retinal cells and structures. We observed the inner retina to be profoundly affected by MS, including nerve fiber bundle thinning, enlarged and lower density retinal ganglion cells, and the presence of microcysts. Longitudinal quantification of inner retinal changes enabled by AO-OCT may help accelerate the development of novel therapies for MS patients.

Conference Presentation

Citation Download Citation

Daniel X. Hammer, Zhuolin Liu, Katherine Kovalick, Osamah Saeedi, and Daniel M. Harrison "Adaptive optics: optical coherence tomography imaging of the inner retina in multiple sclerosis", Proc. SPIE PC11941, Ophthalmic Technologies XXXII, PC1194106 (7 March 2022); https://doi.org/10.1117/12.2608765

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