Birefringent properties of the peripapillary retinal nerve fiber layer in healthy and glaucoma subjects using polarisation-sensitive optical coherence tomography

Stefan Steiner; Florian Schwarzhans; Sylvia Desissaire; Hemma Resch; Georg Fischer; Michael Pircher; Christoph K. Hitzenberger; Clemens Vass

doi:10.1117/12.2608841

7 March 2022 Birefringent properties of the peripapillary retinal nerve fiber layer in healthy and glaucoma subjects using polarisation-sensitive optical coherence tomography

Stefan Steiner, Florian Schwarzhans, Sylvia Desissaire, Hemma Resch, Georg Fischer, Michael Pircher, Christoph K. Hitzenberger, Clemens Vass

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Proceedings Volume PC11941, Ophthalmic Technologies XXXII; PC1194115 (2022) https://doi.org/10.1117/12.2608841
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Glaucoma is one of the leading causes of irreversible blindness worldwide. The disease causes the loss of retinal nerve fibers (RNFs) and therefore visual field impairment. It is thought that in the early stages of glaucoma, before the loss of RNFs, the intracellular microtubules of the RNF axons disappear, altering the birefringent properties of the RNF-Layer (RNFL). In this study, we measured the birefringent properties of the RNFL using a polarization-sensitive OCT to compare glaucoma vs. healthy eyes. We observed a significantly reduced birefringence of the RNFL in glaucoma compared to healthy controls (0.090 ±0.009°/µm vs. 0.100 ±0.010°/µm, p<0.001).

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Stefan Steiner, Florian Schwarzhans, Sylvia Desissaire, Hemma Resch, Georg Fischer, Michael Pircher, Christoph K. Hitzenberger, and Clemens Vass "Birefringent properties of the peripapillary retinal nerve fiber layer in healthy and glaucoma subjects using polarisation-sensitive optical coherence tomography", Proc. SPIE PC11941, Ophthalmic Technologies XXXII, PC1194115 (7 March 2022); https://doi.org/10.1117/12.2608841

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KEYWORDS

Nerve

Optical coherence tomography

Birefringence

Control systems

Axons

Visualization

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