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7 March 2022 Clinical translation of intracranial pressure sensing with diffuse correlation spectroscopy
Syeda M. Tabassum, Alexander Ruesch, Deepshikha Acharya, Jason Yang, Jaskaran Rakkar, Robert S. B. Clark, Michael M. McDowell, Jana M Kainerstorfer
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Proceedings Volume PC11945, Clinical and Translational Neurophotonics 2022; PC119450A (2022) https://doi.org/10.1117/12.2610429
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Current standard-of-care methods for measuring intracranial pressure (ICP) are highly invasive. To overcome this limitation, we recently demonstrated non-invasive quantification of ICP in an animal model using morphological analysis of the pulsatile cerebral blood flow (CBF) measured with Diffuse Correlation Spectroscopy. Here, we present results from a pilot study in pediatric patients admitted to an intensive care unit. We show that the CBF pulsatile waveform changes with ICP. Using a regression forest-based machine learning algorithm on a cohort of patients (n>15) we demonstrate that ICP extraction in humans can be possible, suggesting the potential for successful clinical translation in future.
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Syeda M. Tabassum, Alexander Ruesch, Deepshikha Acharya, Jason Yang, Jaskaran Rakkar, Robert S. B. Clark, Michael M. McDowell, and Jana M Kainerstorfer "Clinical translation of intracranial pressure sensing with diffuse correlation spectroscopy", Proc. SPIE PC11945, Clinical and Translational Neurophotonics 2022, PC119450A (7 March 2022); https://doi.org/10.1117/12.2610429
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KEYWORDS
Spectroscopy
Animal model studies
Cerebral blood flow
Data acquisition
Machine learning
Morphological analysis
Pathology
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