CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume PC11947 > Article
Presentation
7 March 2022 Excitatory and inhibitory neuromodulation induced by a single infrared light pulse
Xuedong Zhu, Jen-Wei Lin, Michelle Sander
Author Affiliations +
Proceedings Volume PC11947, Optogenetics and Optical Manipulation 2022; PC1194705 (2022) https://doi.org/10.1117/12.2607152
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
We found that a single and brief IR light pulse induced a TTX-independent membrane depolarization, whose amplitude depends on the pulse duration and total energy deposition. The depolarization facilitated action potential (AP) generation when the axon was near firing threshold. This depolarization was followed by a membrane hyperpolarization at higher energy levels, which reversed near potassium equilibrium potential and could inhibit AP firing. Pharmacological results indicated that barium-sensitive potassium channels contributed to the hyperpolarization, while further administration of TEA did not change the hyperpolarization. We show that individual and brief IR light pulses can evoke both excitatory and inhibitory effects.
Conference Presentation
© (2022) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Xuedong Zhu, Jen-Wei Lin, and Michelle Sander "Excitatory and inhibitory neuromodulation induced by a single infrared light pulse", Proc. SPIE PC11947, Optogenetics and Optical Manipulation 2022, PC1194705 (7 March 2022); https://doi.org/10.1117/12.2607152
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Infrared radiation
Axons
Modulation
Potassium
Barium
Fiber amplifiers
Laser sources
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top