Neurovascular coupling changes as a result of head-fixed body tilt in awake mice

Juan Cortes; Harsha Sridhar; Deepshikha Acharya; Jana M. Kainerstorfer; Alberto L. Vazquez

doi:10.1117/12.2647887

17 March 2023 Neurovascular coupling changes as a result of head-fixed body tilt in awake mice

Juan Cortes, Harsha Sridhar, Deepshikha Acharya, Jana M. Kainerstorfer, Alberto L. Vazquez

Proceedings Volume PC12365, Neural Imaging and Sensing 2023; PC1236507 (2023) https://doi.org/10.1117/12.2647887
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Neurovascular coupling, the interplay between neurons and the vasculature, is thought be essential to sustain brain function. This coupling mechanism can be very sensitive to pathologies that Increase Intracranial Pressure (ICP). Head Fixed Body Tilt (HFBT) experiments were conducted in awake mice to induce changes in ICP. Images sensitive to neuronal and vascular responses were acquired during whisker stimulation and rest before, during and after body tilting. Resting state data was used to extract Hemodynamic Responses Functions (HRF) using a double gamma model. Changes in the shape of the HRF were used to assess the impact of potential changes in ICP. We also analyzed resting state imaging data to characterize the potential effects of ICP on hemodynamic responses across brain regions.

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Juan Cortes, Harsha Sridhar, Deepshikha Acharya, Jana M. Kainerstorfer, and Alberto L. Vazquez "Neurovascular coupling changes as a result of head-fixed body tilt in awake mice", Proc. SPIE PC12365, Neural Imaging and Sensing 2023, PC1236507 (17 March 2023); https://doi.org/10.1117/12.2647887

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KEYWORDS

Neurovascular coupling

Brain

Hemodynamics

Sensors

Convolution

Data acquisition

Head

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