Design and characterization of handheld multiphoton probe for intraoral imaging

Tyler Peterson; Hongzhang Ma; Paula Villarreal; Xingde Li; Gracie Vargas; Rongguang Liang

doi:10.1117/12.2657635

6 March 2023 Design and characterization of handheld multiphoton probe for intraoral imaging

Tyler Peterson, Hongzhang Ma, Paula Villarreal, Xingde Li, Gracie Vargas, Rongguang Liang

Proceedings Volume PC12370, Design and Quality for Biomedical Technologies XVI; PC1237007 (2023) https://doi.org/10.1117/12.2657635
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Multiphoton fluorescence imaging allows clinicians to identify early signs of oral cancer at its origin below the tissue surface. The high resolution required for adequate morphological assessment is only possible over a relatively small field of view, however, so an additional co-registered wide field of view, low resolution image is crucial for efficient device operation. To meet this need, we present the design of a handheld intraoral probe that includes a 0.50NA objective for multiphoton imaging and auxiliary cameras for region-of-interest identification. Because multiphoton image quality is most dependent on the high NA objective, we characterize its performance and correlate findings to expected system-level quality. Finally, we show concepts for the design and manufacturing strategy of a compact, monolithic, high NA freeform prism objective optimized for multiphoton imaging in the oral cavity.

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Citation Download Citation

Tyler Peterson, Hongzhang Ma, Paula Villarreal, Xingde Li, Gracie Vargas, and Rongguang Liang "Design and characterization of handheld multiphoton probe for intraoral imaging", Proc. SPIE PC12370, Design and Quality for Biomedical Technologies XVI, PC1237007 (6 March 2023); https://doi.org/10.1117/12.2657635

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KEYWORDS

Image quality

Image resolution

Cameras

Cancer

Design for manufacturability

Manufacturing

Multiphoton fluorescence microscopy

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