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7 March 2023 Bioluminescence tomography-guided system for pre-clinical pancreatic cancer research
Zijian Deng, Xiangkun Xu, Hamid Dehghani, Juvenal Reyes, John Wong, Phuoc Tran, Ken Kang-Hsin Wang
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Proceedings Volume PC12376, Optical Tomography and Spectroscopy of Tissue XV; PC123760S (2023) https://doi.org/10.1117/12.2649242
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
The challenge to study radiotherapy for pre-clinical pancreatic ductal adenocarcinoma(PDAC) is lack of image-guided system providing strong soft-tissue contrast. Bioluminescence imaging is an attractive solution, but it is inadequate to localize movable PDAC at single projection. With these targeting uncertainties, large radiation beam is commonly used. Therefore, we innovated bioluminescence tomography(BLT) to guide conformal irradiation for PDAC. Our BLT could retrieve orthotopic PDAC volume within 0.5-2mm accuracy at 2-6mm depth, even tumor located at various locations at given study days. Our BLT offers unique opportunities to localize PDAC for conformal irradiation, reduce normal tissue toxicity, and therefore increase study reproducibility.
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Zijian Deng, Xiangkun Xu, Hamid Dehghani, Juvenal Reyes, John Wong, Phuoc Tran, and Ken Kang-Hsin Wang "Bioluminescence tomography-guided system for pre-clinical pancreatic cancer research", Proc. SPIE PC12376, Optical Tomography and Spectroscopy of Tissue XV, PC123760S (7 March 2023); https://doi.org/10.1117/12.2649242
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KEYWORDS
Pancreatic cancer
Bioluminescence
Tumors
Pre-clinical research
Tissues
Toxicity
Animal model studies
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