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13 March 2024 First clinical experience with self-propelled retrograde tethered capsule endomicroscopy (R-TCE)
Du-Ri Song, Tara C. Lignelli, John J. McDaniel, Alissa A. Cirio, Ara L. Bablouzian, Paola A. Alarcon, Long H. Nguyen, Rachel Smith, Matthew Beatty, Zachary D. Jansa, Catriona N. Grant, Hamed Khalili, Guillermo J. Tearney
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Proceedings Volume PC12820, Endoscopic Microscopy XIX; PC128200E (2024) https://doi.org/10.1117/12.3007956
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
In our first clinical experience, we have found that Retrograde Tethered Capsule Endomicroscopy (R-TCE) was able to be advanced ~ 30 cm in 3 minutes in the colon of an unsedated study subject. R-TCE imaging enabled full circumferential OCT visualization of 96.60 ± 0.22 (95% CI) of the human colon wall. 3D rendered flythroughs of R-TCE OCT images demonstrate comprehensive visualization behind colonic folds where pre-neoplastic lesions may be missed by colonoscopy. The R-TCE procedure was well-tolerated, there were no complications, and a sigmoidoscopy conducted after the procedure did not show any R-TCE-related mucosal damage.
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Du-Ri Song, Tara C. Lignelli, John J. McDaniel, Alissa A. Cirio, Ara L. Bablouzian, Paola A. Alarcon, Long H. Nguyen, Rachel Smith, Matthew Beatty, Zachary D. Jansa, Catriona N. Grant, Hamed Khalili, and Guillermo J. Tearney "First clinical experience with self-propelled retrograde tethered capsule endomicroscopy (R-TCE)", Proc. SPIE PC12820, Endoscopic Microscopy XIX, PC128200E (13 March 2024); https://doi.org/10.1117/12.3007956
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KEYWORDS
Colon
Endomicroscopy
Optical coherence tomography
Sigmoidoscopy
3D image processing
Tissues
Visualization
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