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13 March 2024 IDH targeted fluorescence guided surgery in low grade gliomas
Linton Evans, Lei G. Wang, Augustino V. Scorzo, Rendall Strawbridge, Scott C. Davis, Summer Gibbs
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Proceedings Volume PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X; PC128250S (2024) https://doi.org/10.1117/12.3023422
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Gross total resection of low grade gliomas is associated with prolonged time to malignant transformation and ultimately overall survival. Unfortunately, rates of gross total resection are reported to be as low as 20-40%. Current strategies in fluorescence guidance are lacking for low grade gliomas and represent an unmet need. We have developed a novel fluorescence exploiting the highly conserved IDH mutant protein that is present in >80% of these tumors. To date there are well described small molecule IDH mutant inhibitors in clinical trial. We describe the development of small molecule fluorescent inhibitors of the IDH mutant protein and their potential applications in surgery for LGG.
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Linton Evans, Lei G. Wang, Augustino V. Scorzo, Rendall Strawbridge, Scott C. Davis, and Summer Gibbs "IDH targeted fluorescence guided surgery in low grade gliomas", Proc. SPIE PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X, PC128250S (13 March 2024); https://doi.org/10.1117/12.3023422
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KEYWORDS
Fluorescence
Surgery
Target designation
Tumors
Resection
Blood brain barrier
Molecules
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