Development of an implantable platform for long-term bio-sensing in the context of pain management

Kiang Wei Kho; Gavin Byrne; Sanathana Konugolu; Jean de Souza Matias; Walter Messina; Michelle Roche; David Finn; Brian McQuire; Simon Riou; Stefan Andersoon-Engels

doi:10.1117/12.3002727

13 March 2024 Development of an implantable platform for long-term bio-sensing in the context of pain management

Kiang Wei Kho, Gavin Byrne, Sanathana Konugolu, Jean de Souza Matias, Walter Messina, Michelle Roche, David Finn, Brian McQuire, Simon Riou, Stefan Andersoon-Engels

Author Affiliations +

Proceedings Volume PC12850, Optical Diagnostics and Sensing XXIV: Toward Point-of-Care Diagnostics; PC128500J (2024) https://doi.org/10.1117/12.3002727
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Chronic-pain (CP) affects at least 10% of the world’s population, and costs our society $1T. There is currently no effective approach to treating CP. To this end, there is an urgent need in the pain-research community to enable monitoring pain-related biomarkers, e.g. circulating DNAs, cytokines, endocannabinoids, over a long-period of time (> 3 months). Here, we show how implant incorporated with photonic nanomaterials known as upconversion nanoparticles (UCNP) are particularly suited for such purposes. We will argue that the unique optical properties of UCNP make possible a simpler wearable readout electronics with low power consumption, thus greatly prolonging operation time.

Citation Download Citation

Kiang Wei Kho, Gavin Byrne, Sanathana Konugolu, Jean de Souza Matias, Walter Messina, Michelle Roche, David Finn, Brian McQuire, Simon Riou, and Stefan Andersoon-Engels "Development of an implantable platform for long-term bio-sensing in the context of pain management", Proc. SPIE PC12850, Optical Diagnostics and Sensing XXIV: Toward Point-of-Care Diagnostics, PC128500J (13 March 2024); https://doi.org/10.1117/12.3002727

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available