Prof. Xiaojing Gong Profile

Prof. Xiaojing Gong

Associate Professor at Shenzhen Institutes of Advanced Technology, CAS

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Publications (7)

Proceedings Article | 20 November 2019 Paper

High-speed intravascular photoacoustic imaging with blood flushing

Chengyou Shu, Zhihua Xie, Daya Yang, Zhiyi Chen, Liang Song, Xiaojing Gong

Proceedings Volume 11190, 111901V (2019) https://doi.org/10.1117/12.2537147

KEYWORDS: Imaging systems, Photoacoustic spectroscopy, High speed imaging, In vivo imaging, Inflammation, Blood, Photoacoustic imaging, Laser development, Intravascular ultrasound, Metals

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Proceedings Article | 20 November 2019 Paper

Carotid atherosclerosis detection using photoacoustic imaging system

Zhihua Xie, Chengyou Shu, Xiaojing Gong, Liang Song

Proceedings Volume 11190, 111902T (2019) https://doi.org/10.1117/12.2537649

KEYWORDS: Inflammation, Photoacoustic imaging, Arteries, In vivo imaging, Blood, Photoacoustic spectroscopy, Imaging systems, Light scattering, Laser scattering, Oxygen

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Carotid arteries are important channels delivering blood and oxygen to brain. Atherosclerosis plaque in carotid arteries hinders blood delivery, and plaque rupture causes stroke, leading to high morbidity and motility. Extensive preclinical and clinical studies showed that atherosclerosis inflammation activities are highly related to plaque vulnerability. Thus, visualizing the inflammation of atherosclerosis plaques is important in atherosclerosis vulnerability assessment. In this study, photoacoustic imaging modality was applied for carotid atherosclerosis inflammation identification of mouse in vivo. Deficient apolipoprotein E (ApoE-/-) mice with high-fat diet and normal diet for 16 weeks were employed as atherosclerosis models and control models, respectively. Photoacoustic molecular probes with optical absorption at nearinfrared wavelength and specifically target cluster of differentiation 36 (CD36) were employed to mark inflammation cells in carotid atherosclerosis plaques of mouse in vivo. Noninvasive imaging of atherosclerosis inflammation cells marked by molecular probes was performed by point-to-point scanning with a custom-built acoustic-resolution photoacoustic imaging system. Considering low scattering of near-infrared light in tissues and mature commercialization of laser, excitation wavelength in this research is chosen at 1064 nm. Carotid arteries with and without atherosclerosis plaques have been noninvasively imaged and distinguished. Furthermore, carotid atherosclerosis with different inflammation severity has been analyzed by photoacoustic imaging and immunohistochemistry staining. Photoacoustic signal from atherosclerosis arteries showed high relativity with inflammation severity defined by immunohistochemistry staining, evidencing the reliability of the novel imaging technology in atherosclerosis inflammation identification. This study paves the way for photoacoustic imaging technology to atherosclerosis inflammation identification, severity quantification and even further atherosclerosis therapy.

SPIE Journal Paper | 24 September 2018 Open Access

Compact and low-cost handheld quasibright-field linear-array probe design in photoacoustic computed tomography

Yuanyuan Bai, Bing Cong, Xiaojing Gong, Liang Song, Chengbo Liu

JBO, Vol. 23, Issue 12, 121606, (September 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.12.121606

KEYWORDS: Photoacoustic spectroscopy, Ultrasonography, Transducers, Prostate, Photoacoustic tomography, Acoustics, Signal to noise ratio, Laser energy, Imaging systems, Signal detection

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SPIE Journal Paper | 8 May 2018 Open Access

Dual-foci detection in photoacoustic computed tomography with coplanar light illumination and acoustic detection: a phantom study

Xiangwei Lin, Chengbo Liu, Jing Meng, Xiaojing Gong, Riqiang Lin, Mingjian Sun, Liang Song

JBO, Vol. 23, Issue 05, 050501, (May 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.5.050501

KEYWORDS: Transducers, Photoacoustic tomography, Acoustics, Signal detection, Imaging systems, Signal to noise ratio, Data acquisition, Quartz, Ultrasonics, Sensors

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SPIE Journal Paper | 23 April 2018 Open Access

Three-dimensional Hessian matrix-based quantitative vascular imaging of rat iris with optical-resolution photoacoustic microscopy in vivo

Huangxuan Zhao, Guangsong Wang, Riqiang Lin, Xiaojing Gong, Liang Song, Tan Li, Wenjia Wang, Kunya Zhang, Xiuqing Qian, Haixia Zhang, Lin Li, Zhicheng Liu, Chengbo Liu

JBO, Vol. 23, Issue 04, 046006, (April 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.4.046006

KEYWORDS: Algorithm development, 3D image processing, Iris recognition, Iris, Vascular imaging, Blood vessels, Image processing, Photoacoustic imaging, In vivo imaging, Imaging systems

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SPIE Journal Paper | 22 June 2015 Open Access

High-speed intravascular spectroscopic photoacoustic imaging at 1000 A-lines per second with a 0.9-mm diameter catheter

Yan Li, Xiaojing Gong, Chengbo Liu, Riqiang Lin, William Hau, Xiaosong Bai, Liang Song

JBO, Vol. 20, Issue 06, 065006, (June 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.6.065006

KEYWORDS: Photoacoustic spectroscopy, Spectroscopy, Imaging spectroscopy, Imaging systems, Photoacoustic imaging, Intravascular ultrasound, Absorption, Optical parametric oscillators, Laser energy, Image resolution

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Proceedings Article | 3 March 2014 Paper

Integrated intravascular ultrasound and optical-resolution photoacoustic microscopy with a 1-mm-diameter catheter

Xiaosong Bai, Xiaojing Gong, Riqiang Lin, William Hau, Liang Song

Proceedings Volume 8943, 894308 (2014) https://doi.org/10.1117/12.2037017

KEYWORDS: Intravascular ultrasound, Photoacoustic spectroscopy, Imaging systems, Image resolution, Photoacoustic imaging, Ultrasonics, Photoacoustic microscopy, Tissue optics, Integrated optics, Ultrasonography

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Showing 5 of 7 publications

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