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13 March 2024 Three-dimensional characterization of murine ovary elasticity using quantitative micro-elastography.
Matt Hepburn, Anna Jaeschke, Alireza Mowla, Chii J. Chan, Brendan F. Kennedy
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Proceedings Volume PC12844, Optical Elastography and Tissue Biomechanics XI; PC128440B (2024) https://doi.org/10.1117/12.3006718
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Tissue elasticity regulates the reproductive function of the mammalian ovary. However, characterizing micro-scale elasticity of entire intact ovaries in three-dimensions (3-D) remains challenging. This limits our ability to study how the elasticity of different ovarian structures, such a follicles, oocytes, and corpus luteum, as well as the entire ovary, affect ovarian function. In this work, for the first time, we extend quantitative micro-elastography to characterize 3-D micro-scale elasticity of entire murine ovaries. We demonstrate distinct elasticity patterns of key ovarian structures as well as changes in tissue elasticity with age.
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Matt Hepburn, Anna Jaeschke, Alireza Mowla, Chii J. Chan, and Brendan F. Kennedy "Three-dimensional characterization of murine ovary elasticity using quantitative micro-elastography.", Proc. SPIE PC12844, Optical Elastography and Tissue Biomechanics XI, PC128440B (13 March 2024); https://doi.org/10.1117/12.3006718
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KEYWORDS
Elasticity
Ovary
Atomic force microscopy
Tissues
Biology
Diseases and disorders
Elastography
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