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19 April 2017 Algorithmic processing of intrinsic signals in affixed transmission speckle analysis (ATSA) (Conference Presentation)
Michael T. Ghijsen, Bruce J. Tromberg
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Proceedings Volume 10063, Dynamics and Fluctuations in Biomedical Photonics XIV; 100630A (2017) https://doi.org/10.1117/12.2253522
Event: SPIE BiOS, 2017, San Francisco, California, United States
Abstract
Affixed Transmission Speckle Analysis (ATSA) is a method recently developed to measure blood flow that is based on laser speckle imaging miniaturized into a clip-on form factor the size of a pulse-oximeter. Measuring at a rate of 250 Hz, ATSA is capable or obtaining the cardiac waveform in blood flow data, referred to as the Speckle-Plethysmogram (SPG). ATSA is also capable of simultaneously measuring the Photoplethysmogram (PPG), a more conventional signal related to light intensity. In this work we present several novel algorithms for extracting physiologically relevant information from the combined SPG-PPG waveform data. First we show that there is a slight time-delay between the SPG and PPG that can be extracted computationally. Second, we present a set of frequency domain algorithms that measure harmonic content on pulse-by-pulse basis for both the SPG and PPG. Finally, we apply these algorithms to data obtained from a set of subjects including healthy controls and individuals with heightened cardiovascular risk. We hypothesize that the time-delay and frequency content are correlated with cardiovascular health; specifically with vascular stiffening.
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View presentation recording on the SPIE Digital Library: http://dx.doi.org/10.1117/12.2253522.5371893399001
© (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
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Michael T. Ghijsen and Bruce J. Tromberg "Algorithmic processing of intrinsic signals in affixed transmission speckle analysis (ATSA) (Conference Presentation)", Proc. SPIE 10063, Dynamics and Fluctuations in Biomedical Photonics XIV, 100630A (19 April 2017); https://doi.org/10.1117/12.2253522
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KEYWORDS
Signal processing
Speckle analysis
Blood circulation
Control systems
Laser development
Laser speckle imaging
Algorithm development
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