Paper
28 July 2017 A technique for measuring oxygen saturation in biological tissues based on diffuse optical spectroscopy
Mikhail Kleshnin, Anna Orlova, Mikhail Kirillin, German Golubiatnikov, Ilya Turchin
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Abstract
A new approach to optical measuring blood oxygen saturation was developed and implemented. This technique is based on an original three-stage algorithm for reconstructing the relative concentration of biological chromophores (hemoglobin, water, lipids) from the measured spectra of diffusely scattered light at different distances from the probing radiation source. The numerical experiments and approbation of the proposed technique on a biological phantom have shown the high reconstruction accuracy and the possibility of correct calculation of hemoglobin oxygenation in the presence of additive noise and calibration errors. The obtained results of animal studies have agreed with the previously published results of other research groups and demonstrated the possibility to apply the developed technique to monitor oxygen saturation in tumor tissue.
© (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Mikhail Kleshnin, Anna Orlova, Mikhail Kirillin, German Golubiatnikov, and Ilya Turchin "A technique for measuring oxygen saturation in biological tissues based on diffuse optical spectroscopy", Proc. SPIE 10412, Diffuse Optical Spectroscopy and Imaging VI, 1041212 (28 July 2017); https://doi.org/10.1117/12.2284378
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Cited by 3 scholarly publications.
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KEYWORDS
Diffuse optical spectroscopy

Tissues

Blood

Oxygen

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