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14 March 2018 Objective dynamic changes in lens curvature during accommodation using optical coherence tomography images (Conference Presentation)
Siobhan Williams, Giovanni Gregori, Marco Ruggeri, Yu-Cherng Chang, Florence Cabot, Arthur Ho, Sonia Yoo, Jean-Marie Parel, Fabrice Manns
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Proceedings Volume 10474, Ophthalmic Technologies XXVIII; 1047419 (2018) https://doi.org/10.1117/12.2295005
Event: SPIE BiOS, 2018, San Francisco, California, United States
Abstract
Purpose: To objectively quantify dynamic changes in lens shape during accommodation using two-dimensional OCT images Methods: In-vivo responses to an accommodative step stimulus of three subjects (aged 22, 39, and 45) were captured using a custom-made extended-depth SD-OCT system operating at 840 nm following an IRB-approved protocol (Ruggeri et al. 2012). Subjects focused on a visual accommodation target designed to produce an adjustable step stimulus of accommodation. Accommodative responses to 2-D and 4-D stimuli were captured ~1.5s before and ~4.5s after stimulation. Lens thickness, anterior curvature, and posterior curvature were measured using a newly-developed algorithm (validated using a calibration sphere). Dynamic changes in lens thickness and curvature were then fitted with an exponential model to produce time dependent constants. Results: All calibration OCT images were automatically analyzed in under 2 seconds. A radius of 7.793mm ± 0.051mm was calculated resulting in a difference of 2.4μm from the reported nominal value of the calibration sphere. Anterior lens radius decreased over time in all subjects. Radius of the posterior lens experienced a slight increase for all subjects. Conclusion: This study demonstrates the feasibility of quantifying the dynamic changes in lens curvature and thickness during accommodation using extended-depth OCT combined with a step accommodation stimulus and an automated segmentation algorithm.
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Siobhan Williams, Giovanni Gregori, Marco Ruggeri, Yu-Cherng Chang, Florence Cabot, Arthur Ho, Sonia Yoo, Jean-Marie Parel, and Fabrice Manns "Objective dynamic changes in lens curvature during accommodation using optical coherence tomography images (Conference Presentation)", Proc. SPIE 10474, Ophthalmic Technologies XXVIII, 1047419 (14 March 2018); https://doi.org/10.1117/12.2295005
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KEYWORDS
Optical coherence tomography
Calibration
Optical spheres
Detection and tracking algorithms
Image analysis
In vivo imaging
Visualization
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