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We present and validate a forward model for modeling light propagation in brain tissue. The model is a dynamic light scattering Monte Carlo simulation that tracks the dynamic scattering events of a photon through a brain tissue geometry. We use the simulation to create a simulated laser speckle contrast image, and compare the simulated image with experimental images.
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David R. Miller, Chakameh Z. Jafari, Colin T. Sullender, Samuel A. Mihelic, Ahmed M. Hassan, Andrew K. Dunn, "Computational speckle contrast optical tomography," Proc. SPIE 10877, Dynamics and Fluctuations in Biomedical Photonics XVI, 1087707 (1 March 2019); https://doi.org/10.1117/12.2512456