Actinic keratosis (AK) is a common cutaneous neoplasm resulting from severe solar damage. Noninvasive diagnosis and grading of AK are important not just because of AK’s precancerous nature, but also due to the frequent presence of multiple AKs.
Here we study the clinical applicability of in vivo harmonic generation microscopy (HGM) for the grading, diagnosis, and treatment assessment of AKs. As a result, 100% agreement on diagnosis and grading outcomes between HGM and traditional histopathology were obtained. Our study indicates the superior capability of in vivo HGM for diagnosis, grading, and treatment assessment of AKs.
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