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We developed combined diffuse reflectance spectroscopy – near-infrared diffuse correlation spectroscopy system. Cuff occlusion test, blood phantom test and test with anesthetic agents in a rat model were conducted for system verification. When the result of system verification follows the expected change in hemoglobin concentration change and the result of test with anesthetic agents shows effect of agents, then we can say that this combined system can be used for monitoring depth of anesthesia. This verified system can be used as the system for establishment of brain disease biomarker under anesthesia state.
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Yoonho Oh, Myeongsu Seong, Sungchul Kim, Seonghyun Kim, Jae Gwan Kim, "Optimization of DRS-DCS system for measurement of tissue metabolism (Conference Presentation)," Proc. SPIE 11216, Multiscale Imaging and Spectroscopy, 112160I (9 March 2020); https://doi.org/10.1117/12.2545913