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While the use of non-targeted dyes may be useful for fluorescence-guided surgery (FGS) in certain diseases, specific contrast agents are essential in oncology. As shown in the latest published clinical studies, monoclonal antibodies display all the characteristics that are necessary to play a major role in this field of medical imaging provided the antigenic target is relevant. Based on clinical data from FGS and from antibody expertise, major parameters explaining why antibodies are favorite FGS tools in oncology will be discussed as well as the remaining challenges for their development.
André Pèlegrin,Marian Gutowski, andFrançoise Cailler
"Antibodies, favorite tools for fluorescence-guided surgery (Conference Presentation)", Proc. SPIE 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI, 112220L (10 March 2020); https://doi.org/10.1117/12.2552361
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André Pèlegrin, Marian Gutowski, Françoise Cailler, "Antibodies, favorite tools for fluorescence-guided surgery (Conference Presentation)," Proc. SPIE 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI, 112220L (10 March 2020); https://doi.org/10.1117/12.2552361