Wide-field intraoperative polarization sensitive and angiographic optical coherence tomography of in vivo non-human primate peripheral nerve (Conference Presentation)

Mohsen Erfanzadeh; Ahhyun S. Nam; Marek Hansdorfer; Kasey Kwong; Mark A. Randolph; Robert W. Redmond; Benjamin J. Vakoc

doi:10.1117/12.2544939

10 March 2020 Wide-field intraoperative polarization sensitive and angiographic optical coherence tomography of in vivo non-human primate peripheral nerve (Conference Presentation)

Mohsen Erfanzadeh, Ahhyun S. Nam, Marek Hansdorfer, Kasey Kwong, Mark A. Randolph, Robert W. Redmond, Benjamin J. Vakoc

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Proceedings Volume 11251, Label-free Biomedical Imaging and Sensing (LBIS) 2020; 112510M (2020) https://doi.org/10.1117/12.2544939
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We demonstrate wide-field intraoperative in vivo PS-OCT and OCT-A imaging of non-human primate (NHP) peripheral nerves using a portable OCT prototype. Imaging was performed on healthy and surgically repaired (12 months after graft surgery) radial nerves in upper extremity of rhesus macaques (n=17) over surgically exposed nerve segments of up to 8 cm in length. We describe the capabilities and challenges of PS-OCT and OCT-A in assessing NHP peripheral nerves. Further, guided by imaging of NHP peripheral nerves, we discuss the required advancements in core polarimetry techniques to enhance the prospects of clinical utility of PS-OCT in peripheral nerve imaging.

Conference Presentation

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Mohsen Erfanzadeh, Ahhyun S. Nam, Marek Hansdorfer, Kasey Kwong, Mark A. Randolph, Robert W. Redmond, and Benjamin J. Vakoc "Wide-field intraoperative polarization sensitive and angiographic optical coherence tomography of in vivo non-human primate peripheral nerve (Conference Presentation)", Proc. SPIE 11251, Label-free Biomedical Imaging and Sensing (LBIS) 2020, 112510M (10 March 2020); https://doi.org/10.1117/12.2544939

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KEYWORDS

Nerve

Optical coherence tomography

Angiography

In vivo imaging

Polarization

Tissue optics

Axons

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