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We have developed a wearable Near Infrared Spectroscopy (NIRS) device to measure the placental oxygenation. The device comprises of six source-detector distances to probe the oxygenation at different tissues. We have measured NIRS signals and tissue thickness in 12 healthy, singleton, pregnant volunteers (week 33.3±3.6 pregnancy). The placental oxygenation calculated for this group ranges from 68% to 89%. However, we found that the calculated placental oxygenation is positively correlated with the thickness of the fat layer. Hence, we are now performing a Monte Carlo simulation on a five-layer model to correct the effect of fat on placental oxygenation.
Thien Nguyen,Kosar Khaksari,Siddharth M. Khare,Roberto Romero, andAmir H. Gandjbakhche
"Oxygenation measurement of placenta tissue during pregnancy using near infrared spectroscopy", Proc. SPIE 11638, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables II, 1163804 (5 March 2021); https://doi.org/10.1117/12.2582790
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Thien Nguyen, Kosar Khaksari, Siddharth M. Khare, Roberto Romero, Amir H. Gandjbakhche, "Oxygenation measurement of placenta tissue during pregnancy using near infrared spectroscopy," Proc. SPIE 11638, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables II, 1163804 (5 March 2021); https://doi.org/10.1117/12.2582790