A multi-laboratory comparison of photon migration instruments and their performances: the BitMap exercise

Sri Rama Pranav Kumar Lanka; Lin Yang; David Orive-Miguel; Joshua Deepak Veesa; Susanna Tagliabue; Aleh Sudakou; Saeed Samaei; Mario Forcione; Zuzana Kovacsova; Anurag Behera; Thomas Gladytz; Dirk Grosenick; Lionel Hervé; Giuseppe Lo Presti; Lorenzo Cortese; Turgut Durduran; Karolina Bejm; Magdalena Morawiec; Piotr Sawosz; Michal Kacprzak; Anna Gerega; Adam Liebert; Antonio Belli; Ilias Tachtsidis; Frédéric Lange; Gemma Bale; Luca Baratelli; Sylvain Gioux; Alexander Kalyanov; Martin Wolf; Sanathana Konugolu Venkata Sekar; Marta Zanoletti; Ileana Pirovano; Michele Lacerenza; Lina Qiu; Edoardo Ferocino; Giulia Maffeis; Caterina Amendola; Lorenzo Colombo; Mauro Buttafava; Marco Renna; Laura Di Sieno; Rebecca Re; Andrea Farina; Lorenzo Spinelli; Alberto Dalla Mora; Davide Contini; Alessandro Torricelli; Alberto Tosi; Paola Taroni; Hamid Dehghani; Heidrun Wabnitz; Antonio Pifferi

doi:10.1117/12.2578521

5 March 2021 A multi-laboratory comparison of photon migration instruments and their performances: the BitMap exercise

Sri Rama Pranav Kumar Lanka, Lin Yang, David Orive-Miguel, Joshua Deepak Veesa, Susanna Tagliabue, Aleh Sudakou, Saeed Samaei, Mario Forcione, Zuzana Kovacsova, Anurag Behera, Thomas Gladytz, Dirk Grosenick, Lionel Hervé, Giuseppe Lo Presti, Lorenzo Cortese, Turgut Durduran, Karolina Bejm, Magdalena Morawiec, Piotr Sawosz, Michal Kacprzak, Anna Gerega, Adam Liebert, Antonio Belli, Ilias Tachtsidis, Frédéric Lange, Gemma Bale, Luca Baratelli, Sylvain Gioux, Alexander Kalyanov, Martin Wolf, Sanathana Konugolu Venkata Sekar, Marta Zanoletti, Ileana Pirovano, Michele Lacerenza, Lina Qiu, Edoardo Ferocino, Giulia Maffeis, Caterina Amendola, Lorenzo Colombo, Mauro Buttafava, Marco Renna, Laura Di Sieno, Rebecca Re, Andrea Farina, Lorenzo Spinelli, Alberto Dalla Mora, Davide Contini, Alessandro Torricelli, Alberto Tosi, Paola Taroni, Hamid Dehghani, Heidrun Wabnitz, Antonio Pifferi

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Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 116390F (2021) https://doi.org/10.1117/12.2578521
Event: SPIE BiOS, 2021, Online Only

Abstract

Performance assessment and standardization are indispensable for instruments of clinical relevance in general and clinical instrumentation based on photon migration/diffuse optics in particular. In this direction, a multi-laboratory exercise was initiated with the aim of assessing and comparing their performances. 29 diffuse optical instruments belonging to 11 partner institutions of a European level Marie Curie Consortium BitMap1 were considered for this exercise. The enrolled instruments covered different approaches (continuous wave, CW; frequency domain, FD; time domain, TD and spatial frequency domain imaging, SFDI) and applications (e.g. mammography, oximetry, functional imaging, tissue spectroscopy). 10 different tests from 3 well-accepted protocols, namely, the MEDPHOT2 , the BIP3 , and the nEUROPt4 protocols were chosen for the exercise and the necessary phantoms kits were circulated across labs and institutions enrolled in the study. A brief outline of the methodology of the exercise is presented here. Mainly, the design of some of the synthetic descriptors, (single numeric values used to summarize the result of a test and facilitate comparison between instruments) for some of the tests will be discussed.. Future actions of the exercise aim at deploying these measurements onto an open data repository and investigating common analysis tools for the whole dataset.

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Sri Rama Pranav Kumar Lanka, Lin Yang, David Orive-Miguel, Joshua Deepak Veesa, Susanna Tagliabue, Aleh Sudakou, Saeed Samaei, Mario Forcione, Zuzana Kovacsova, Anurag Behera, Thomas Gladytz, Dirk Grosenick, Lionel Hervé, Giuseppe Lo Presti, Lorenzo Cortese, Turgut Durduran, Karolina Bejm, Magdalena Morawiec, Piotr Sawosz, Michal Kacprzak, Anna Gerega, Adam Liebert, Antonio Belli, Ilias Tachtsidis, Frédéric Lange, Gemma Bale, Luca Baratelli, Sylvain Gioux, Alexander Kalyanov, Martin Wolf, Sanathana Konugolu Venkata Sekar, Marta Zanoletti, Ileana Pirovano, Michele Lacerenza, Lina Qiu, Edoardo Ferocino, Giulia Maffeis, Caterina Amendola, Lorenzo Colombo, Mauro Buttafava, Marco Renna, Laura Di Sieno, Rebecca Re, Andrea Farina, Lorenzo Spinelli, Alberto Dalla Mora, Davide Contini, Alessandro Torricelli, Alberto Tosi, Paola Taroni, Hamid Dehghani, Heidrun Wabnitz, and Antonio Pifferi "A multi-laboratory comparison of photon migration instruments and their performances: the BitMap exercise", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 116390F (5 March 2021); https://doi.org/10.1117/12.2578521

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