Preliminary clinical study of the potential of multi-modal optical/ultrasound LUCA platform for improved thyroid cancer screening

Lorenzo Cortese; Giuseppe Lo Presti; Pablo Fernandez Esteberena; Marta Zanoletti; Mauro Buttafava; Marco Renna; Davide Contini; Alberto Dalla Mora; Antonio Pifferi; Paola Taroni; Alberto Tosi; Gloria Aranda; Sabina Ruiz Janer; Mattia Squarcia; Felicia Hanzu; Mireia Mora Porta; Stanislaw Wojtkiewicz; Hamid Dehghani; Udo M. Weigel; Sixte de Fraguier; An Nguyen-Dinh; Bogdan Rosinski; Turgut Durduran

doi:10.1117/12.2577248

5 March 2021 Preliminary clinical study of the potential of multi-modal optical/ultrasound LUCA platform for improved thyroid cancer screening

Lorenzo Cortese, Giuseppe Lo Presti, Pablo Fernandez Esteberena, Marta Zanoletti, Mauro Buttafava, Marco Renna, Davide Contini, Alberto Dalla Mora, Antonio Pifferi, Paola Taroni, Alberto Tosi, Gloria Aranda, Sabina Ruiz Janer, Mattia Squarcia, Felicia Hanzu, Mireia Mora Porta, Stanislaw Wojtkiewicz, Hamid Dehghani, Udo M. Weigel, Sixte de Fraguier, An Nguyen-Dinh, Bogdan Rosinski, Turgut Durduran

Author Affiliations +

Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 116390L (2021) https://doi.org/10.1117/12.2577248
Event: SPIE BiOS, 2021, Online Only

Abstract

The LUCA device combines clinical ultrasound, time-domain near infrared and diffuse correlation spectroscopies with the aim of improving thyroid cancer screening sensitivity and specificity. The preliminary clinical campaign on patients (n=31) with thyroid nodules and healthy controls (n=11) allowed the characterization of the precision of the instrument and demonstrated that using a couple of biomarkers the muscle-to-nodule contrast allows an area under the curve of 0.92 for single-nodule patients and 0.77 for all patients in differentiating benign and malignant nodules in a receiver operating characteristic curve. We will present the updated results from the ongoing study.

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Lorenzo Cortese, Giuseppe Lo Presti, Pablo Fernandez Esteberena, Marta Zanoletti, Mauro Buttafava, Marco Renna, Davide Contini, Alberto Dalla Mora, Antonio Pifferi, Paola Taroni, Alberto Tosi, Gloria Aranda, Sabina Ruiz Janer, Mattia Squarcia, Felicia Hanzu, Mireia Mora Porta, Stanislaw Wojtkiewicz, Hamid Dehghani, Udo M. Weigel, Sixte de Fraguier, An Nguyen-Dinh, Bogdan Rosinski, and Turgut Durduran "Preliminary clinical study of the potential of multi-modal optical/ultrasound LUCA platform for improved thyroid cancer screening", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 116390L (5 March 2021); https://doi.org/10.1117/12.2577248

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