Mapping human brain function with massively parallel high-speed three-dimensional photoacoustic computed tomography

Shuai Na; Jonathan Russin; Li Lin; Xiaoyun Yuan; Peng Hu; Kay Jann; Lirong Yan; Konstantin Maslov; Junhui Shi; Danny Wang; Charles Liu; Lihong Wang

doi:10.1117/12.2582652

2 June 2021 Mapping human brain function with massively parallel high-speed three-dimensional photoacoustic computed tomography

Shuai Na, Jonathan Russin, Li Lin, Xiaoyun Yuan, Peng Hu, Kay Jann, Lirong Yan, Konstantin Maslov, Junhui Shi, Danny Wang, Charles Liu, Lihong Wang

Author Affiliations +

Proceedings Volume 11642, Photons Plus Ultrasound: Imaging and Sensing 2021; 116420F (2021) https://doi.org/10.1117/12.2582652
Event: SPIE BiOS, 2021, Online Only

Abstract

Photoacoustic computed tomography (PACT) has been extensively explored in animal brains but never in the human brain due to its limited field of view (FOV), imaging speed, penetration depth, and sensitivity. Here, we present the first application of PACT in functional human brain imaging. Motor and language functional tasks were employed and performed by post-hemicraniectomy patients. The brain activities were recorded at a 10-cm–diameter FOV, 350-μm/2-s spatiotemporal resolution, and ~2-cm penetration depth using a newly developed massively parallel three-dimensional PACT system. Quantitative validation of the PACT results against 7 Tesla MRI revealed comparable angiographic structures and functional activation in the same FOV. The obtained results represent a critical step toward broader-scope human brain imaging applications using PACT technology.

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Shuai Na, Jonathan Russin, Li Lin, Xiaoyun Yuan, Peng Hu, Kay Jann, Lirong Yan, Konstantin Maslov, Junhui Shi, Danny Wang, Charles Liu, and Lihong Wang "Mapping human brain function with massively parallel high-speed three-dimensional photoacoustic computed tomography", Proc. SPIE 11642, Photons Plus Ultrasound: Imaging and Sensing 2021, 116420F (2 June 2021); https://doi.org/10.1117/12.2582652

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