Calibration free, time-resolved diffuse optical spectroscopy using combined Monte-Carlo and diffusion theory

Michael Helton; Carter McMaster; Mary-Ann Mycek; Karthik Vishwanath

doi:10.1117/12.2583283

5 March 2021 Calibration free, time-resolved diffuse optical spectroscopy using combined Monte-Carlo and diffusion theory

Michael Helton, Carter McMaster, Mary-Ann Mycek, Karthik Vishwanath

Author Affiliations +

Proceedings Volume 11657, Biomedical Applications of Light Scattering XI; 116570M (2021) https://doi.org/10.1117/12.2583283
Event: SPIE BiOS, 2021, Online Only

Abstract

Near-infrared spectroscopy has been widely employed in biophotonics to study and quantify the optical properties of biological tissues. Unlike steady-state approaches, time-resolved spectroscopic techniques enable optical absorption and scattering properties of the medium to be separated, allowing for quantitation of depth-dependent absolute tissue optical properties. However, robust analysis of time-resolved signals requires careful consideration of calibration techniques and computational models. Here, we consider the effect of the time window employed when fitting a diffusion theory model to Monte-Carlo simulations. Next, we describe the impact of the temporal position of the instrument response function (IRF) in recovery of the optical properties. Finally, we discuss a technique to analyze time-resolved measurements without knowledge of the timescale of the IRF or the time-resolved measurement by fitting the relative shape of the photons’ distribution time-of-flight (DTOF).

Conference Presentation

Citation Download Citation

Michael Helton, Carter McMaster, Mary-Ann Mycek, and Karthik Vishwanath "Calibration free, time-resolved diffuse optical spectroscopy using combined Monte-Carlo and diffusion theory", Proc. SPIE 11657, Biomedical Applications of Light Scattering XI, 116570M (5 March 2021); https://doi.org/10.1117/12.2583283

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