4D digital breast phantom for contrast-enhanced imaging

Dan Li; Andrey Makeev; Stephen J. Glick

doi:10.1117/12.2655537

7 April 2023 4D digital breast phantom for contrast-enhanced imaging

Dan Li, Andrey Makeev, Stephen J. Glick

Proceedings Volume 12463, Medical Imaging 2023: Physics of Medical Imaging; 124630I (2023) https://doi.org/10.1117/12.2655537
Event: SPIE Medical Imaging, 2023, San Diego, California, United States

Abstract

A 4D digital phantom model for contrast-enhanced breast imaging was developed in this work. The model is based on an anthropomorphic digital breast 3D phantom, which gives the user good control of the 4D phantom for developing and optimizing contrast enhancement imaging techniques. The fourth dimension of the phantom features different time-varying enhancement patterns for different materials including fibro-glandular tissue and lesion tissue. Physiological parameters that capture the key characteristics of masses, for example, wash-in and wash-out rates¹ and indications of metabolic level, are employed in the model to simulate certain fundamental features for categorizing mass types. The two-compartmental model,² a well-known model in the field of Pharmacokinetics, is used to depict the diffusion process of the contrast agent. Two methods are proposed to allow for the simulations of lesions with necrotic cores of varying shapes and sizes. With the contrast agent in the tissue, higher contrast is achieved between fibro-glandular tissue and mass tissue according to the mammograms simulated by Monte Carlo method.³

Conference Presentation

Citation Download Citation

Dan Li, Andrey Makeev, and Stephen J. Glick "4D digital breast phantom for contrast-enhanced imaging", Proc. SPIE 12463, Medical Imaging 2023: Physics of Medical Imaging, 124630I (7 April 2023); https://doi.org/10.1117/12.2655537

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