First-generation clinical dual-source photon-counting CT: quantitative and ultra-high-resolution spectral imaging

Lisa Heck; Leening P. Liu; Pouyan Pasyar; Kai Mei; Julia Herzen; Harold I. Litt; Peter B. Noël

doi:10.1117/12.2651439

7 April 2023 First-generation clinical dual-source photon-counting CT: quantitative and ultra-high-resolution spectral imaging

Lisa Heck, Leening P. Liu, Pouyan Pasyar, Kai Mei, Julia Herzen, Harold I. Litt, Peter B. Noël

Author Affiliations +

Proceedings Volume 12463, Medical Imaging 2023: Physics of Medical Imaging; 1246320 (2023) https://doi.org/10.1117/12.2651439
Event: SPIE Medical Imaging, 2023, San Diego, California, United States

Conference Poster

Abstract

Dual-source photon-counting computed tomography (PCCT) enables a novel ultra-high-resolution (UHR) scanning mode that can provide UHR conventional images (0.2 mm) as well as spectral results (0.4 mm). To evaluate the spatial resolution and quantitative capabilities of the UHR mode, with a focus on thoracic imaging, a PixelPrint lung phantom mimicking interstitial lung disease with honeycombing and iodine rods of different diameters and concentrations directly attached to the phantom were scanned at doses from 1.0 to 7.5 mGy. Virtual monoenergetic images at 50 keV, virtual non-contrast, and iodine density maps at 0.4 and 1 mm slice thickness were reconstructed as well as conventional images at 0.2, 0.4, and 1 mm slice thickness, all with standard lung and quantitative reconstruction kernels (matrix size 512x512). Iodine quantification was performed for the attached rods, and clinically relevant features in the lung phantom were utilized to evaluate spatial resolution. Overall, iodine quantification was stable across radiation dose, reconstruction kernels, and slice thickness with errors of 0.25, 0.20, and 0.40 mg/mL for 1, 2, and 5 mg/mL iodine, respectively. Even the smallest iodine core rod was detected in the extended CT phantom for a higher dose. For the diseased lung region, images at 0.2 mm slice thickness appeared sharper and depicted smaller structures better, even with increased noise in comparison to thicker slices. In conclusion, UHR mode demonstrated high spatial resolution with detection of small features and accurate iodine quantification, which may provide diagnostic advantage to thoracic imaging with more precise and accurate information.

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Lisa Heck, Leening P. Liu, Pouyan Pasyar, Kai Mei, Julia Herzen, Harold I. Litt, and Peter B. Noël "First-generation clinical dual-source photon-counting CT: quantitative and ultra-high-resolution spectral imaging", Proc. SPIE 12463, Medical Imaging 2023: Physics of Medical Imaging, 1246320 (7 April 2023); https://doi.org/10.1117/12.2651439

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