Intrinsically disordered proteins in anhydrobiosis challenge the cognition of traditional proteins

Pengcheng Xiong

doi:10.1117/12.2669624

24 March 2023 Intrinsically disordered proteins in anhydrobiosis challenge the cognition of traditional proteins

Pengcheng Xiong

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 1261106 (2023) https://doi.org/10.1117/12.2669624
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Anhydrobiosis, a phenomenon which organisms copy with desiccation stress through a dormancy with reversible halt of metabolism, has been studied since the 18th century and left researchers with many mysteries. Organisms finish this difficult task with several strategies including the assist of intrinsic disordered proteins (IDPs). IDPs are a novel class of proteins with the lack of orderly structure, and they participate in anhydrobiosis and are essential for desiccation tolerance. The correlation between their low conservation in sequence, changing structure and extensive functions breaks through the limitations of traditional proteins’ paradigm, and challenges people's understanding of traditional proteins. This review focuses on the characteristics of late embryogenesis abundant (LEA) proteins and tardigrade intrinsically disordered proteins (TDPs), which are the most widely studied and latest researched IDPs, in sequence, structure and function, and summarizes the existing conundrum current researches, to provide insight for IDPs in anhydrobiosis and rethink the complex relationship between sequence, structure and function of proteins.

Citation Download Citation

Pengcheng Xiong "Intrinsically disordered proteins in anhydrobiosis challenge the cognition of traditional proteins", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 1261106 (24 March 2023); https://doi.org/10.1117/12.2669624

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