The mechanism of HDAC6 affecting the progress of non-small cell lung cancer

Yuchen Zhang

doi:10.1117/12.2669374

24 March 2023 The mechanism of HDAC6 affecting the progress of non-small cell lung cancer

Yuchen Zhang

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 1261123 (2023) https://doi.org/10.1117/12.2669374
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Non-small cell lung cancer (NSCLC) is a kind of cancer occurring frequently which is difficult to diagnose and cure. There hasn't been much advancement in the search for a cure. In recent years, the development of epigenetics has reminded scientists that epigenetic dysregulation may be a hint of the tumor. Especially, the high expression of histone acetylase 6 (HDAC6）in NSCLC has aroused great concern among researchers. They investigated whether HDAC6 has a significant impact on the occurrence and progression of NSCLC in a number of trials. HDAC6 can catalyze the deacetylation of α- tubulin and participate in tubulin-related cellular pathways, thus affecting the migration of tumor cells. HDAC6 also possesses ubiquitin enzyme activity, which has a hand in the ubiquitin-proteasome pathway to degrade the substrate. According to reports, HDAC6's role in drug resistance is connected to this function. Therefore, with the support of those findings, the researchers have a future to further explore new targets for the treatment of NSCLC and ways to reduce the drug resistance of tumor cells. This review will summarize the latest research advances of some investigators and discuss whether these advances may provide new approaches for the treatment of NSCLC.

Citation Download Citation

Yuchen Zhang "The mechanism of HDAC6 affecting the progress of non-small cell lung cancer", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 1261123 (24 March 2023); https://doi.org/10.1117/12.2669374

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KEYWORDS

Proteins

Lung cancer

Tumors

Cancer

Resistance

Lung

Signal processing

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