The COVID-19 pandemic is a once-in-a-lifetime public health threat. The pandemic has had a significant impact on both individuals and communities’ health, safety, and well-being. Because COVID-19 is an extremely infectious and has nonspecific symptoms that are easily confused with the typical flu, it is critical to have precise diagnostic techniques readily available. There is an urgent need for quick detection of the SARS-CoV-2 virus due to the COVID-19 pandemic. Here, we present highly sensitive gold nanoparticle-enhanced localized surface plasmon resonance (LSPR) technique for detection of SARS-CoV-2 virus. Surface plasmon resonance is a powerful method for getting label-free, real-time information about the interaction of two binding partners. Gold nanoparticles (AuNPs) were used as signal enhancers in the diagnosis of SARS-CoV- 2 virus using the LSPR technique. Gold nanoparticles are stable against oxidation, great biocompatible, non-cytotoxic and have unique optical characteristics. These specific properties make AuNPs the most potential nanomaterial for different applications such as ultrasensitive detection and biological sensing.
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