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This study presents the results of classification of autofluorescence (AF) and diffuse reflectance (DR) spectra obtained in vivo on skin Basal Cell Carcinomas (BCC) and Squamous Cell Carcinomas (SCC), Actinic Keratoses (AK) and Healthy skin (H) of 140 patients. The bimodal spectroscopic instrument used in this study uses five LEDs for fluorescence excitation at wavelengths peaks between 365 and 415 nm, and a xenon lamp featuring 350-800 nm emission range to obtain AF and DR spectra for four source-detector distances (from 400 to 1000 μm). The classification (C vs H, H vs AK) was done by support vector machine, discriminant analysis, and multilayer perceptron. Final accuracy of two-class classification tests for almost all pairs of classes was more than 80%. This study presents a comparison of the performance of these combination of methods with the standard clinical procedure. |
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