Mechanism of photodynamic inactivation of hepatocarcinoma cells with sulfonated aluminum phthalocyanine

Hong-Yu Yu; Rong-Chun Dong; Ji-Yao Chen; Huai-Xin Cai

doi:10.1117/12.137020

5 March 1993 Mechanism of photodynamic inactivation of hepatocarcinoma cells with sulfonated aluminum phthalocyanine

Hong-Yu Yu, Rong-Chun Dong, Ji-Yao Chen, Huai-Xin Cai

Proceedings Volume 1616, International Conference on Photodynamic Therapy and Laser Medicine; (1993) https://doi.org/10.1117/12.137020
Event: International Conference on Photodynamic Therapy and Laser Medicine, 1991, Beijing, China

Abstract

The mechanism of photodynamic therapy (PDT) with sulfonated aluminum phthalocyanine (AlSPC) studied with the human hepatocellular carcinoma cell line in culture is reported herein. Photofrin II (PII) was chosen as the control photosensitizer of AlSPC. Deuterium oxide (D₂O), an enhancer of singlet oxygen (¹O₂); 1,3-diphenylisobenzofuran (DPBF), a quencher of ¹O₂: glycerol, a quencher of OH radical (OH(DOT)); superoxide dismutase (SOD), a quencher of O₂^- radical (O₂^-(DOT)); diethyldithiocarbamate (DDC), an inhibitor of SOD and glutathione peroxidase; were introduced into both the processes of photodynamic inactivation of human liver cancer cells in culture with AlSPC (AlSPC-PDT) and with PII (PII-PDT). The results suggest that: ¹O₂ is dominantly involved in both PII-PDT and AlSPC-PDT; O₂^-(DOT) is involved in AlSPC-PDT in a lower degree than ¹O₂, while almost not involved in PII-PDT; OH(DOT) is involved in PII-PDT in a lower degree than ¹O₂, while almost not involved in AlSPC-PDT.

Citation Download Citation

Hong-Yu Yu, Rong-Chun Dong, Ji-Yao Chen, and Huai-Xin Cai "Mechanism of photodynamic inactivation of hepatocarcinoma cells with sulfonated aluminum phthalocyanine", Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); https://doi.org/10.1117/12.137020

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