Photodynamic laser therapy with antibody-coupled phthalocyanine

Birgit C. Schultes; Stefan B. Spaniol; Stephan Schmidt; Wolfgang Ertmer; Hans-Juergen Biersack; Dieter Krebs

doi:10.1117/12.168709

1 March 1994 Photodynamic laser therapy with antibody-coupled phthalocyanine

Birgit C. Schultes, Stefan B. Spaniol, Stephan Schmidt, Wolfgang Ertmer, Hans-Juergen Biersack, Dieter Krebs

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168709
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

We developed a new water-soluble phthalocyanine, activated for coupling to antibodies by N- hydroxysulfosuccinimide. The efficiency of anti-CA125-phthalocyanine conjugates was compared to free phthalocyanine in a human ovarian carcinoma model in tissue culture. In both cases a dose dependent cell killing was observed after irradiation with a Titanium sapphire laser at 675 nm and 50 J/cm², but incubation with antibody-coupled phthalocyanine resulted in 90% cell mortality with a 60-130-fold lower dye application.

Citation Download Citation

Birgit C. Schultes, Stefan B. Spaniol, Stephan Schmidt, Wolfgang Ertmer, Hans-Juergen Biersack, and Dieter Krebs "Photodynamic laser therapy with antibody-coupled phthalocyanine", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168709

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