Wavelength dependence of nanosecond pulsed laser ablation of atherosclerotic coronary artery

Dido M. Yova; Kyriakos A. Kassis; Theodoros Mouroutis; Nikolaos Kavantzas; Emanuel Agapitos; Dimitrios Koutsouris; Alexander A. Serafetinides

doi:10.1117/12.197579

23 December 1994 Wavelength dependence of nanosecond pulsed laser ablation of atherosclerotic coronary artery

Dido M. Yova, Kyriakos A. Kassis, Theodoros Mouroutis, Nikolaos Kavantzas, Emanuel Agapitos, Dimitrios Koutsouris, Alexander A. Serafetinides

Author Affiliations +

Proceedings Volume 2327, Medical Applications of Lasers II; (1994) https://doi.org/10.1117/12.197579
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

Pulsed laser ablation of atheromatous arteries was studied at three wavelengths in the near ultraviolet, visible, and near infrared regions of the spectrum. The experiments were done with an Nd:YAG laser, 9 nsec pulse duration. The wavelength could be fixed at 1064 nm, 532 nm, or 355 nm through KDP crystals. Laser fluences ranged up to 80 J/cm² and repetition rate was 8 Hz. Ablation fluence thresholds increased with wavelength from UV to the visible region and dropped again near (lambda) equals 1064 nm. Maximum ablation efficiency at 355 nm was measured to be 0.6 mg/J, three times higher than the corresponding value at either 532 or 1064 nm, which was approximately 0.20 mg/J. The results are in good correlation with the optical properties of cardiovascular tissue, assuming that the absorption coefficients are equal to (mu) _a approximately equals 24 cm^-1 at 355 nm, and (mu) _a approximately equals 1.32 cm^-1 at 532 or 1064 nm. Corresponding the scattering coefficients assumed to be equal to 8 cm^-1 at 355 nm and 20 cm^-1 at 532 and 1064 nm. Taking into consideration the composite nature of calcified lesions, the optical properties of cardiovascular tissues, and the different possibilities of the three wavelengths the choice of pulsed Nd:YAG laser with KDP crystals capability seems to be a good choice for angioplasty.

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Dido M. Yova, Kyriakos A. Kassis, Theodoros Mouroutis, Nikolaos Kavantzas, Emanuel Agapitos, Dimitrios Koutsouris, and Alexander A. Serafetinides "Wavelength dependence of nanosecond pulsed laser ablation of atherosclerotic coronary artery", Proc. SPIE 2327, Medical Applications of Lasers II, (23 December 1994); https://doi.org/10.1117/12.197579

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