Applications of 3D finite element modeling to the study of ventricular physiology

Michael J. Moulton; Lawrence L. Creswell; Ning S. Hu; Ricardo L. Actis; Kent W. Myers; Barna A. Szabo; Michael K. Pasque

doi:10.1117/12.209706

24 May 1995 Applications of 3D finite element modeling to the study of ventricular physiology

Michael J. Moulton, Lawrence L. Creswell, Ning S. Hu, Ricardo L. Actis, Kent W. Myers, Barna A. Szabo, Michael K. Pasque

Author Affiliations +

Proceedings Volume 2433, Medical Imaging 1995: Physiology and Function from Multidimensional Images; (1995) https://doi.org/10.1117/12.209706
Event: Medical Imaging 1995, 1995, San Diego, CA, United States

Abstract

A 3D, nonlinear finite element (FE) model of the diastolic canine heart was constructed from multislice magnetic resonance images (MRI). The model was solved using the p-version of the FE method to predict stress and deformation in diastole. Finite element models were employed in an 'inverse' problem to estimate the nonlinear material properties of intact diastolic myocardium. Additionally, FE models were employed to examine the effects of RV pressure overload on LV pressure-volume (P- V) relationships in the pathologic heart. A 3D, nonlinear FE model had 1,704 degrees of freedom and 8 elements, it had a maximum principal stress value of 429,127 dynes/cm² and a minimum principal stress of -344,599 dynes/cm² at p equals 6. Average nonlinear material parameters estimated for 6 dogs were E equals 28,722 +/- 15,984 dynes/cm² and c equals 0.00182 +/- 0.00232 cm²/dyne. Examination of the effects of RV pressure increase on LV P-V relationships indicated substantially different effects of RV pressure overload on the different pathologic conditions (p < 0.005 by ANOVA) with increasing RV pressure having a more pronounced effect on the dilated heart than the hypertrophied heart. When the mechanical effects of the pericardium were included in the model, at higher RV pressures, all of the pressure-volume (P-V) curves became similar indicating that at higher RV pressures, the P-V curves were independent of ventricular shape and material properties and depended only on the RV pressure. In conclusion, FE models of the heart were constructed from MRI images of the heart and were employed to study diastolic ventricular function in the normal and pathologic heart.

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Michael J. Moulton, Lawrence L. Creswell, Ning S. Hu, Ricardo L. Actis, Kent W. Myers, Barna A. Szabo, and Michael K. Pasque "Applications of 3D finite element modeling to the study of ventricular physiology", Proc. SPIE 2433, Medical Imaging 1995: Physiology and Function from Multidimensional Images, (24 May 1995); https://doi.org/10.1117/12.209706

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KEYWORDS

Heart

3D modeling

Chemical elements

Magnetic resonance imaging

Finite element methods

3D image processing

Mathematical modeling

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