DNA/europium ion interaction by matrix-assisted laser desorption time-of-flight mass spectrometry

Stephanie Bourin; Daniel McStay; Paul Kong Thoo Lin; Gary Duncan; Jim Lomax

doi:10.1117/12.274343

22 May 1997 DNA/europium ion interaction by matrix-assisted laser desorption time-of-flight mass spectrometry

Stephanie Bourin, Daniel McStay, Paul Kong Thoo Lin, Gary Duncan, Jim Lomax

Proceedings Volume 2985, Ultrasensitive Biochemical Diagnostics II; (1997) https://doi.org/10.1117/12.274343
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

The interaction of DNA and lanthanide ions using Matrix assisted laser desorption time of flight mass spectrometry. 2', 4', 6' hydroxy acetophenone was the matrix used, and Europium chloride was the lanthanide salt used to interact with Adenine and Guanine containing synthetic oligonucleotides. The MALDI analysis permitted the detection of DNA/Europium adducts and also provided information on the stoichiometry of the interaction.

Citation Download Citation

Stephanie Bourin, Daniel McStay, Paul Kong Thoo Lin, Gary Duncan, and Jim Lomax "DNA/europium ion interaction by matrix-assisted laser desorption time-of-flight mass spectrometry", Proc. SPIE 2985, Ultrasensitive Biochemical Diagnostics II, (22 May 1997); https://doi.org/10.1117/12.274343

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