Gd-DTPA-enhanced magnetic resonance imaging (MRI) for the follow-up of laser-induced thermotherapy (LITT): trial to determine a useful examination schedule

Christoph-Thomas Germer; Christoph Martin Isbert; Dirk Albrecht; Joerg-Peter Ritz; Andreas Schilling; Andre Roggan; Karl Juergen Wolf; Gerhard J. Mueller; Heinz-Johannes Buhr

doi:10.1117/12.300826

19 January 1998 Gd-DTPA-enhanced magnetic resonance imaging (MRI) for the follow-up of laser-induced thermotherapy (LITT): trial to determine a useful examination schedule

Christoph-Thomas Germer, Christoph Martin Isbert, Dirk Albrecht, Joerg-Peter Ritz, Andreas Schilling, Andre Roggan, Karl Juergen Wolf, Gerhard J. Mueller, Heinz-Johannes Buhr

Author Affiliations +

Proceedings Volume 3193, Photothermal Therapies in Medicine; (1998) https://doi.org/10.1117/12.300826
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

Purpose: To evaluate gadolinium-DTPA-enhanced MRI for follow-up monitoring of laser-induced thermotherapy (LITT) and to determine of a useful examination schedule. Materials and Methods: LITT Of the liver was performed in 55 rabbits using a Nd:YAG laser (4 w power output, 840 s exposure time). Gd-DTPA MRI and histological examinations were performed at different times (0 - 168 days). Results: Laser- induced lesions underwent regeneration and volume size reduction (69% after 168 days). The correlation coefficient (MR vs macroscopic analysis) for the mean lesion diameter was r equals 0.96. Histology of lesions comprised the four zones that correlated best with MRI findings. Coagulation necroses immediately after LITT were seen as an area of no enhancement on Gd-DTPA MRI. Circular enhancement was first seen 72 - 96 hours after LITT, which was due to early mesenchymal proliferation. Conclusions: Gd-DTPA MRI is a good monitoring procedure for LITT. MRI should be performed 24 and 96 hours after LITT.

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Christoph-Thomas Germer, Christoph Martin Isbert, Dirk Albrecht, Joerg-Peter Ritz, Andreas Schilling, Andre Roggan, Karl Juergen Wolf, Gerhard J. Mueller, and Heinz-Johannes Buhr "Gd-DTPA-enhanced magnetic resonance imaging (MRI) for the follow-up of laser-induced thermotherapy (LITT): trial to determine a useful examination schedule", Proc. SPIE 3193, Photothermal Therapies in Medicine, (19 January 1998); https://doi.org/10.1117/12.300826

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