Early diagnosis of gastric cancer with laser-induced fluorescence

Alexander Y. Joffe; Valeriy F. Sayenko; Nikolay A. Denisov; Sergiy M. Dets; Alexander N. Buryi

doi:10.1117/12.339186

12 February 1999 Early diagnosis of gastric cancer with laser-induced fluorescence

Alexander Y. Joffe, Valeriy F. Sayenko, Nikolay A. Denisov, Sergiy M. Dets, Alexander N. Buryi

Proceedings Volume 3567, Optical and Imaging Techniques for Biomonitoring IV; (1999) https://doi.org/10.1117/12.339186
Event: BiOS Europe '98, 1998, Stockholm, Sweden

Abstract

Optical biopsy of stomach mucosa was performed afterwards oral administration of encapsulated hyperflav (single dose was chosen to provide 0.1 - 0.15 mg/kg b.w.) A sufficient fluorescence contrast of suspicions versus normal tissue was obtained after incubation time from 4 to 10 hours. Fluorescence was induced by He - Cd laser coupled to fiber optic probe inserted into a biopsy channel of the endoscope. Fluorescent spectra were recorded in the range from 500 nm up to 700 nm with 2 nm resolution. We took two groups of patients with benign and malignant ulcer of the stomach and erosive gastritis. The first group consisted of 59 patients (male/female 36/23) was carried out with optical biopsy of stomach mucosa. The second group consisted of 60 patients (male/female 39/21) was carried out by routine method: gastroscopy and biopsy from 5 - 7 places of macroscopically changed mucosa.

Citation Download Citation

Alexander Y. Joffe, Valeriy F. Sayenko, Nikolay A. Denisov, Sergiy M. Dets, and Alexander N. Buryi "Early diagnosis of gastric cancer with laser-induced fluorescence", Proc. SPIE 3567, Optical and Imaging Techniques for Biomonitoring IV, (12 February 1999); https://doi.org/10.1117/12.339186

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